| 1. Round | 22/02/2020 | Deportes Copiapó | - | Deportes Melipilla | 4:1 | ||||
| 2. Round | 03/03/2020 | Deportes Melipilla | - | Deportes Valdivia | 2:0 | ||||
| 3. Round | 07/03/2020 | San Marcos | - | Deportes Melipilla | 1:0 |  |
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| 4. Round | 13/03/2020 | Deportes Melipilla | - | Rangers | 1:0 |  |
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| 9. Round | 16/09/2020 | Deportes Melipilla | - | Cobreloa | 1:1 | ||||
| 10. Round | 22/09/2020 | Barnechea | - | Deportes Melipilla | 0:1 | ||||
| 12. Round | 01/10/2020 | CD Magallanes | - | Deportes Melipilla | 0:0 | ||||
| 13. Round | 05/10/2020 | Deportes Melipilla | - | Santiago Morning | 1:1 | ||||
| 14. Round | 08/10/2020 | Deportes Melipilla | - | Puerto Montt | 2:0 | |
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| 15. Round | 12/10/2020 | Deportes Temuco | - | Deportes Melipilla | 0:3 | ||||
| 16. Round | 28/10/2020 | Deportes Melipilla | - | Deportes Copiapó | 1:2 | ||||
| 17. Round | 04/11/2020 | Ñublense | - | Deportes Melipilla | 4:0 | ||||
| 18. Round | 08/11/2020 | Deportes Melipilla | - | San Luis | 3:0 | ||||
| 19. Round | 12/11/2020 | Puerto Montt | - | Deportes Melipilla | 0:0 | ||||
| 20. Round | 17/11/2020 | Deportes Melipilla | - | CD Magallanes | 0:0 | ||||
| 29. Round | 12/01/2021 | Deportes Melipilla | - | Barnechea | 3:1 | ||||
| 30. Round | 17/01/2021 | Unión San Felipe | - | Deportes Melipilla | 1:1 |
Chile