1. Round | 24/07/2021 | CF Pachuca | - | Club León | 4:0 | ||||
2. Round | 31/07/2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
3. Round | 10/08/2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
11. Round | 29/09/2021 | CF Pachuca | - | CF América | 1:1 | ||||
12. Round | 02/10/2021 | Puebla FC | - | CF Pachuca | 1:2 |