| 2. Round | 27/07/2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 3. Round | 29/07/2021 | Arsenal de Sarandí | - | Argentinos Juniors | 1:0 |  |
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| 4. Round | 02/08/2021 | Argentinos Juniors | - | Central Córdoba SdE | 1:1 | ||||
| 5. Round | 08/08/2021 | Boca Juniors | - | Argentinos Juniors | 1:1 | ||||
| 6. Round | 14/08/2021 | Argentinos Juniors | - | Banfield | 2:0 | ||||
| 7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 8. Round | 26/08/2021 | Argentinos Juniors | - | Talleres de Córdoba | 1:2 | |
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| 9. Round | 30/08/2021 | Unión de Santa Fe | - | Argentinos Juniors | 1:0 | ||||
| 10. Round | 06/09/2021 | Estudiantes | - | Argentinos Juniors | 1:1 | ||||
| 11. Round | 15/09/2021 | Argentinos Juniors | - | Patronato de Paraná | 1:1 | ||||
| 12. Round | 19/09/2021 | Platense | - | Argentinos Juniors | 0:0 | |
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| 13. Round | 27/09/2021 | Argentinos Juniors | - | Racing Club | 2:0 | ||||
| 14. Round | 03/10/2021 | Rosario Central | - | Argentinos Juniors | 0:1 | ||||
| 21. Round | 20/11/2021 | Argentinos Juniors | - | Godoy Cruz | 0:0 | ||||
| 22. Round | 24/11/2021 | Vélez Sarsfield | - | Argentinos Juniors | 2:0 | |
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| 25. Round | 11/12/2021 | Argentinos Juniors | - | Sarmiento de Junín | 2:0 |
Argentina