| 1. Round | 01/07/2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 0:2 |  |
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| 2. Round | 08/07/2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 3. Round | 15/07/2022 | Puebla FC [U20] | - | Club León [U20] | 3:1 | ||||
| 4. Round | 23/07/2022 | Cruz Azul [U20] | - | Puebla FC [U20] | 0:0 | |
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| 6. Round | 30/07/2022 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:3 | |
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| 16. Round | 02/08/2022 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 1:2 | ||||
| 7. Round | 06/08/2022 | Puebla FC [U20] | - | Pumas UNAM [U20] | 1:2 | |
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| 8. Round | 12/08/2022 | Club Tijuana [U20] | - | Puebla FC [U20] | 3:4 | ||||
| 10. Round | 20/08/2022 | Atlas Guadalajara [U20] | - | Puebla FC [U20] | 4:0 | ||||
| 11. Round | 26/08/2022 | Puebla FC [U20] | - | FC Juárez [U20] | 2:1 | ||||
| 12. Round | 01/09/2022 | Gallos Blancos [U20] | - | Puebla FC [U20] | 0:2 | ||||
| 13. Round | 07/09/2022 | Puebla FC [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 14. Round | 10/09/2022 | Deportivo Guadalajara [U20] | - | Puebla FC [U20] | 1:1 | ||||
| 9. Round | 13/09/2022 | Puebla FC [U20] | - | Club Necaxa [U20] | 3:2 | |
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| 5. Round | 22/09/2022 | CF Monterrey [U20] | - | Puebla FC [U20] | 3:3 | ||||
| 17. Round | 30/09/2022 | Puebla FC [U20] | - | CF América [U20] | 1:1 |
Mexico