| 1. Round | 26/07/2010 | FCM Târgu Mureş | - | FC Brașov | 0:1 |  |
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| 2. Round | 30/07/2010 | FC Vaslui | - | FCM Târgu Mureş | 1:1 | ||||
| 7. Round | 12/09/2010 | FCM Târgu Mureş | - | Gaz Metan Mediaş | 1:0 | ||||
| 8. Round | 19/09/2010 | CFR Cluj | - | FCM Târgu Mureş | 1:2 | ||||
| 9. Round | 27/09/2010 | FCM Târgu Mureş | - | FC Universitatea Craiova | 1:4 | |
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| 10. Round | 04/10/2010 | FC Victoria Brăneşti | - | FCM Târgu Mureş | 0:0 | ||||
| 11. Round | 16/10/2010 | FCM Târgu Mureş | - | FC Timişoara | 2:3 | |
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| 12. Round | 23/10/2010 | Astra Ploieşti | - | FCM Târgu Mureş | 0:0 | ||||
| 13. Round | 31/10/2010 | FCM Târgu Mureş | - | Sportul Studenţesc | 4:1 | ||||
| 14. Round | 06/11/2010 | Pandurii Târgu Jiu | - | FCM Târgu Mureş | 4:1 | ||||
| 17. Round | 28/11/2010 | Universitatea Cluj | - | FCM Târgu Mureş | 1:1 |
Romania