| 12. Round | 16/10/2010 | Exeter City | - | Carlisle United | 2:1 | ||||
| 13. Round | 23/10/2010 | Carlisle United | - | Charlton Athletic | 3:4 |  |
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| 14. Round | 30/10/2010 | Bristol Rovers | - | Carlisle United | 1:1 | |
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| 15. Round | 02/11/2010 | Carlisle United | - | Tranmere Rovers | 2:0 | ||||
| 16. Round | 13/11/2010 | Carlisle United | - | Southampton FC | 3:2 | ||||
| 17. Round | 20/11/2010 | Walsall FC | - | Carlisle United | 2:1 | |
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| 18. Round | 23/11/2010 | Carlisle United | - | Rochdale AFC | 1:1 | ||||
| 20. Round | 11/12/2010 | Carlisle United | - | Dagenham & Redbridge | 0:2 | ||||
| 24. Round | 01/01/2011 | Carlisle United | - | Huddersfield Town | 2:2 | ||||
| 25. Round | 03/01/2011 | Tranmere Rovers | - | Carlisle United | 2:1 |
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