| 1. Round | 07/08/2022 | FC Groningen | - | FC Volendam | 2:2 | ||||
| 2. Round | 14/08/2022 | AFC Ajax | - | FC Groningen | 6:1 | ||||
| 3. Round | 21/08/2022 | FC Groningen | - | Go Ahead Eagles | 1:0 |  |
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| 4. Round | 26/08/2022 | NEC Nijmegen | - | FC Groningen | 1:1 | ||||
| 5. Round | 04/09/2022 | FC Groningen | - | Vitesse | 0:1 | ||||
| 6. Round | 11/09/2022 | SC Cambuur | - | FC Groningen | 0:1 | ||||
| 7. Round | 17/09/2022 | Sparta Rotterdam | - | FC Groningen | 2:1 | ||||
| 9. Round | 07/10/2022 | FC Groningen | - | RKC Waalwijk | 2:3 | |
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| 10. Round | 16/10/2022 | FC Twente | - | FC Groningen | 3:0 | |
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| 11. Round | 23/10/2022 | FC Groningen | - | PSV Eindhoven | 4:2 | ||||
| 12. Round | 30/10/2022 | FC Emmen | - | FC Groningen | 0:0 | ||||
| 13. Round | 06/11/2022 | FC Utrecht | - | FC Groningen | 2:1 | ||||
| 14. Round | 13/11/2022 | FC Groningen | - | Fortuna Sittard | 2:3 | |
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| 17. Round | 22/01/2023 | sc Heerenveen | - | FC Groningen | 3:1 | ||||
| 19. Round | 29/01/2023 | FC Volendam | - | FC Groningen | 3:2 |
Netherlands