| 2. Round | 17/07/2021 | Rotor Volgograd | - | Olimp-Dolgoprudny | 1:1 |  |
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| 3. Round | 23/07/2021 | Olimp-Dolgoprudny | - | FK Kamaz | 1:1 | ||||
| 5. Round | 08/08/2021 | Olimp-Dolgoprudny | - | Torpedo Moskva | 0:1 | ||||
| 6. Round | 14/08/2021 | Enisey Krasnoyarsk | - | Olimp-Dolgoprudny | 1:0 | ||||
| 9. Round | 05/09/2021 | Olimp-Dolgoprudny | - | Alania Vladikavkaz | 1:1 | ||||
| 10. Round | 11/09/2021 | Tekstilshchik Ivanovo | - | Olimp-Dolgoprudny | 3:1 | ||||
| 11. Round | 15/09/2021 | Olimp-Dolgoprudny | - | Veles Moskva | 0:2 | ||||
| 16. Round | 09/10/2021 | Olimp-Dolgoprudny | - | Fakel Voronezh | 2:0 | ||||
| 17. Round | 13/10/2021 | FK Tom Tomsk | - | Olimp-Dolgoprudny | 1:1 | ||||
| 19. Round | 23/10/2021 | Akron Tolyatti | - | Olimp-Dolgoprudny | 2:1 | ||||
| 20. Round | 31/10/2021 | Olimp-Dolgoprudny | - | Rotor Volgograd | 2:2 | ||||
| 21. Round | 06/11/2021 | FK Kamaz | - | Olimp-Dolgoprudny | 1:1 | ||||
| 22. Round | 13/11/2021 | Olimp-Dolgoprudny | - | FK Krasnodar 2 | 0:1 |
Russia