| 1. Round | 18/07/2021 | Olimp-Dolgoprudny 2 | - | Shinnik Yaroslavl | 1:0 | ||||
| 2. Round | 24/07/2021 | Shinnik Yaroslavl | - | Torpedo Vladimir | 1:0 | ||||
| 3. Round | 01/08/2021 | FK Kazanka Moskva | - | Shinnik Yaroslavl | 0:1 | ||||
| 4. Round | 07/08/2021 | Shinnik Yaroslavl | - | Dinamo Moskva 2 | 3:0 | ||||
| 5. Round | 15/08/2021 | FK Murom | - | Shinnik Yaroslavl | 0:1 | ||||
| 6. Round | 21/08/2021 | Shinnik Yaroslavl | - | FK Volna | 3:0 | ||||
| 7. Round | 29/08/2021 | FK Znamya Truda | - | Shinnik Yaroslavl | 1:3 | ||||
| 20. Round | 05/11/2021 | Shinnik Yaroslavl | - | FK Chertanovo | 3:0 | ||||
| 21. Round | 10/11/2021 | Khimik Dzerzhinsk | - | Shinnik Yaroslavl | 2:2 | ||||
| 22. Round | 14/11/2021 | Shinnik Yaroslavl | - | Olimp-Dolgoprudny 2 | 2:1 |  |
Russia