| 1. Round | 24/07/2021 | FK SKA Rostov | - | Spartak Nalchik | 0:0 |  |
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| 3. Round | 08/08/2021 | FK SKA Rostov | - | Anzhi Makhachkala | 0:1 | ||||
| 4. Round | 15/08/2021 | FK Druzhba | - | FK SKA Rostov | 1:4 |  |
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| 5. Round | 21/08/2021 | FK SKA Rostov | - | Alania-2 Vladikavkaz | 5:0 | ||||
| 6. Round | 29/08/2021 | Kuban-Holding Pavlovskaya | - | FK SKA Rostov | 1:2 | ||||
| 7. Round | 04/09/2021 | FK SKA Rostov | - | Forte Taganrog | 5:2 | ||||
| 9. Round | 12/09/2021 | FK SKA Rostov | - | Rotor-2 Volgograd | 1:0 | ||||
| 10. Round | 20/09/2021 | FK Tuapse | - | FK SKA Rostov | 0:3 dec. | ||||
| 13. Round | 10/10/2021 | Chernomorets Novorossisk | - | FK SKA Rostov | 0:1 | ||||
| 14. Round | 17/10/2021 | FK SKA Rostov | - | FK Yessentuki | 1:0 | ||||
| 15. Round | 23/10/2021 | FK Biolog Novokubansk | - | FK SKA Rostov | 1:3 | |
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| 16. Round | 31/10/2021 | FK SKA Rostov | - | FK Legion Dynamo Makhachkala | 2:1 |  |
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| 17. Round | 06/11/2021 | FK Mashuk KMV | - | FK SKA Rostov | 0:2 | |
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| 18. Round | 14/11/2021 | FK SKA Rostov | - | FK Chayka | 0:2 | ||||
| 19. Round | 19/11/2021 | Anzhi Makhachkala | - | FK SKA Rostov | 0:0 |
Russia