| 1. Round | 18/07/2021 | FK Tver | - | FK Krasava | 3:1 | ||||
| 2. Round | 24/07/2021 | FK Tver | - | FK Chita | 1:1 | ||||
| 4. Round | 07/08/2021 | FK Tver | - | FK Leningradets | 3:0 |  |
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| 14. Round | 04/10/2021 | FK Leningradets | - | FK Tver | 6:1 | ||||
| 17. Round | 19/10/2021 | Luki-Energiya Velikiye Luki | - | FK Tver | 0:1 | ||||
| 18. Round | 25/10/2021 | Zenit St. Petersburg 2 | - | FK Tver | 1:1 | ||||
| 19. Round | 31/10/2021 | FK Tver | - | Zvezda St. Petersburg | 1:0 | ||||
| 20. Round | 05/11/2021 | Dinamo St. Petersburg | - | FK Tver | 1:2 | ||||
| 21. Round | 10/11/2021 | FK Tver | - | FK Kairat Moskva | 3:0 |
Russia