| 1. Round | 27/07/2021 | Esbjerg fB | - | Vendsyssel FF | 1:1 | ||||
| 2. Round | 30/07/2021 | Hobro IK | - | Vendsyssel FF | 1:1 |  |
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| 3. Round | 08/08/2021 | Vendsyssel FF | - | Nykøbing FC | 1:1 | ||||
| 4. Round | 13/08/2021 | FC Helsingør | - | Vendsyssel FF | 3:1 | |
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| 5. Round | 19/08/2021 | Vendsyssel FF | - | AC Horsens | 1:2 | ||||
| 6. Round | 22/08/2021 | Vendsyssel FF | - | FC Fredericia | 1:1 |  |
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| 7. Round | 29/08/2021 | HB Køge | - | Vendsyssel FF | 2:2 | |
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| 9. Round | 19/09/2021 | Hvidovre IF | - | Vendsyssel FF | 3:2 | |
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| 10. Round | 25/09/2021 | Fremad Amager | - | Vendsyssel FF | 1:0 | ||||
| 11. Round | 03/10/2021 | Vendsyssel FF | - | Jammerbugt FC | 2:1 | ||||
| 12. Round | 17/10/2021 | AC Horsens | - | Vendsyssel FF | 1:1 | |
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| 14. Round | 31/10/2021 | FC Fredericia | - | Vendsyssel FF | 4:0 | ||||
| 8. Round | 03/11/2021 | Vendsyssel FF | - | Lyngby BK | 1:1 | ||||
| 15. Round | 07/11/2021 | Vendsyssel FF | - | HB Køge | 4:1 | ||||
| 16. Round | 21/11/2021 | Lyngby BK | - | Vendsyssel FF | 1:0 | ||||
| 18. Round | 04/12/2021 | Nykøbing FC | - | Vendsyssel FF | 1:1 | |
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| 20. Round | 06/03/2022 | Vendsyssel FF | - | Esbjerg fB | 1:0 | |
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| 21. Round | 12/03/2022 | Jammerbugt FC | - | Vendsyssel FF | 0:1 | ||||
| 22. Round | 18/03/2022 | Vendsyssel FF | - | Hvidovre IF | 0:1 | |
Denmark