13. Round | 01/05/2022 | Sol de América | - | Guaraní | 2:2 | ||||
14. Round | 09/05/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
15. Round | 12/05/2022 | Resistencia SC | - | Guaraní | 1:2 | ||||
16. Round | 17/05/2022 | Guaraní | - | 12 de Octubre de Itauguá | 3:0 | ||||
17. Round | 22/05/2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
19. Round | 19/06/2022 | Tacuary | - | Guaraní | 0:2 |