| 1. Round | 23/02/2025 | FC Cincinnati | - | New York RB | 1:0 | ||||
| 2. Round | 02/03/2025 | Philadelphia Union | - | FC Cincinnati | 4:1 | ||||
| 3. Round | 09/03/2025 | FC Cincinnati | - | Toronto FC | 2:0 | ||||
| 4. Round | 15/03/2025 | Charlotte FC | - | FC Cincinnati | 2:0 | ||||
| 6. Round | 30/03/2025 | Nashville SC | - | FC Cincinnati | 1:2 | ||||
| 8. Round | 13/04/2025 | D.C. United | - | FC Cincinnati | 0:1 | ||||
| 9. Round | 20/04/2025 | Chicago Fire | - | FC Cincinnati | 2:3 | ||||
| 10. Round | 26/04/2025 | FC Cincinnati | - | Sporting Kansas City | 2:1 | ||||
| 11. Round | 04/05/2025 | New York City FC | - | FC Cincinnati | 1:0 | ||||
| 12. Round | 11/05/2025 | FC Cincinnati | - | Austin FC | 2:1 | ||||
| 13. Round | 15/05/2025 | Toronto FC | - | FC Cincinnati | 0:1 | ||||
| 14. Round | 18/05/2025 | Columbus Crew | - | FC Cincinnati | 1:1 | ||||
| 15. Round | 26/05/2025 | Atlanta United FC | - | FC Cincinnati | 4:2 |  |
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| 16. Round | 29/05/2025 | FC Cincinnati | - | FC Dallas | 3:3 | ||||
| 17. Round | 01/06/2025 | FC Cincinnati | - | D.C. United | 1:2 |
USA