| 2. Round | 12/09/2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 |  |
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| 4. Round | 25/09/2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 | ||||
| 5. Round | 03/10/2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 6. Round | 17/10/2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | ||||
| 7. Round | 25/10/2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 |  |
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| 8. Round | 29/10/2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 10. Round | 20/11/2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Round | 29/11/2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 12. Round | 04/12/2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | ||||
| 13. Round | 13/12/2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 |  |
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| 14. Round | 18/12/2021 | Ethnikos Achna | - | Anorthosis Famagusta | 0:2 | ||||
| 1. Round | 22/12/2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | |
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| 17. Round | 16/01/2022 | Anorthosis Famagusta | - | AEL Limassol | 2:1 | ||||
| 18. Round | 24/01/2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Round | 29/01/2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 20. Round | 06/02/2022 | Paphos FC | - | Anorthosis Famagusta | 1:1 | |
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Serbia