| 1. Round | 22/08/2010 | 1. FSV Mainz 05 | - | VfB Stuttgart | 2:0 | ||||
| 2. Round | 28/08/2010 | VfL Wolfsburg | - | 1. FSV Mainz 05 | 3:4 | ||||
| 3. Round | 12/09/2010 | 1. FSV Mainz 05 | - | 1. FC Kaiserslautern | 2:1 | ||||
| 4. Round | 18/09/2010 | Werder Bremen | - | 1. FSV Mainz 05 | 0:2 | ||||
| 5. Round | 21/09/2010 | 1. FSV Mainz 05 | - | 1. FC Köln | 2:0 | ||||
| 6. Round | 25/09/2010 | Bayern München | - | 1. FSV Mainz 05 | 1:2 | ||||
| 7. Round | 02/10/2010 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 4:2 | ||||
| 8. Round | 16/10/2010 | 1. FSV Mainz 05 | - | Hamburger SV | 0:1 | ||||
| 9. Round | 24/10/2010 | Bayer Leverkusen | - | 1. FSV Mainz 05 | 0:1 |  |
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| 11. Round | 06/11/2010 | SC Freiburg | - | 1. FSV Mainz 05 | 1:0 | ||||
| 12. Round | 13/11/2010 | 1. FSV Mainz 05 | - | Hannover 96 | 0:1 | ||||
| 14. Round | 26/11/2010 | 1. FSV Mainz 05 | - | 1. FC Nürnberg | 3:0 | ||||
| 15. Round | 04/12/2010 | Eintracht Frankfurt | - | 1. FSV Mainz 05 | 2:1 |
Slovakia