| Preliminary | 09/04/2021 | Palestino | - | Cobresal | 2:1 | ||||
| Group F | 23/04/2021 | Libertad | - | Palestino | 2:0 | ||||
| Group F | 30/04/2021 | Palestino | - | Atlético Goianiense | 0:1 | ||||
| Group F | 05/05/2021 | Palestino | - | Newell's Old Boys | 0:1 | ||||
| Group F | 13/05/2021 | Atlético Goianiense | - | Palestino | 0:0 | ||||
| Group F | 20/05/2021 | Newell's Old Boys | - | Palestino | 3:1 |  |
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| Group F | 25/05/2021 | Palestino | - | Libertad | 1:2 |
Chile