| 6. Round | 18/09/2021 | F91 Dudelange | - | Union Titus Pétange | 3:1 | ||||
| 9. Round | 17/10/2021 | Union Titus Pétange | - | RFCU Luxemburg | 4:2 |  |
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| 10. Round | 23/10/2021 | Progrès Niedercorn | - | Union Titus Pétange | 3:2 | ||||
| 11. Round | 07/11/2021 | US Mondorf | - | Union Titus Pétange | 2:1 | ||||
| 14. Round | 05/12/2021 | Union Titus Pétange | - | Victoria Rosport | 0:3 | ||||
| 20. Round | 06/03/2022 | Union Titus Pétange | - | F91 Dudelange | 0:1 |  |
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| 21. Round | 13/03/2022 | Jeunesse Esch | - | Union Titus Pétange | 1:0 | ||||
| 22. Round | 19/03/2022 | Union Titus Pétange | - | US Hostert | 3:0 | ||||
| 23. Round | 02/04/2022 | RFCU Luxemburg | - | Union Titus Pétange | 0:0 | ||||
| 25. Round | 16/04/2022 | Union Titus Pétange | - | US Mondorf | 1:1 | ||||
| 26. Round | 24/04/2022 | Etzella Ettelbruck | - | Union Titus Pétange | 0:1 | ||||
| 28. Round | 06/05/2022 | Victoria Rosport | - | Union Titus Pétange | 1:1 | |
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| 29. Round | 15/05/2022 | Union Titus Pétange | - | CS FOLA Esch | 0:1 |
Guinea