| 1. Round | 12/08/2018 | Southampton FC | - | Burnley FC | 0:0 | ||||
| 3. Round | 25/08/2018 | Southampton FC | - | Leicester City | 1:2 | ||||
| 4. Round | 01/09/2018 | Crystal Palace | - | Southampton FC | 0:2 | ||||
| 5. Round | 17/09/2018 | Southampton FC | - | Brighton & Hove Albion | 2:2 | ||||
| 7. Round | 29/09/2018 | Wolverhampton Wanderers | - | Southampton FC | 2:0 | ||||
| 9. Round | 20/10/2018 | AFC Bournemouth | - | Southampton FC | 0:0 | ||||
| 10. Round | 27/10/2018 | Southampton FC | - | Newcastle United | 0:0 | ||||
| 11. Round | 04/11/2018 | Manchester City | - | Southampton FC | 6:1 | ||||
| 13. Round | 24/11/2018 | Fulham FC | - | Southampton FC | 3:2 | ||||
| 15. Round | 05/12/2018 | Tottenham Hotspur | - | Southampton FC | 3:1 | ||||
| 19. Round | 27/12/2018 | Southampton FC | - | West Ham United | 1:2 | ||||
| 20. Round | 30/12/2018 | Southampton FC | - | Manchester City | 1:3 | ||||
| 24. Round | 30/01/2019 | Southampton FC | - | Crystal Palace | 1:1 | ||||
| 26. Round | 09/02/2019 | Southampton FC | - | Cardiff City | 1:2 | ||||
| 27. Round | 24/02/2019 | Arsenal FC | - | Southampton FC | 2:0 | ||||
| 37. Round | 04/05/2019 | West Ham United | - | Southampton FC | 3:0 |
Morocco
