| 5. Round | 19/06/2022 | Columbus Crew | - | Charlotte FC | 1:1 | ||||
| 5. Round | 26/06/2022 | Real Salt Lake | - | Columbus Crew | 0:0 | ||||
| 6. Round | 24/07/2022 | Columbus Crew | - | New England Revolution | 0:0 | ||||
| 7. Round | 28/08/2022 | FC Cincinnati | - | Columbus Crew | 2:2 | ||||
| 8. Round | 03/09/2022 | Columbus Crew | - | Chicago Fire | 0:0 | ||||
| 9. Round | 02/10/2022 | Columbus Crew | - | New York RB | 2:1 | ||||
| 9. Round | 09/10/2022 | Orlando City | - | Columbus Crew | 2:1 |
Canada