| 18. Round | 11/02/2022 | Lyon-La Duchère | - | SC Toulon | 2:0 |  |
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| 19. Round | 19/02/2022 | AS Monaco B | - | Lyon-La Duchère | 2:2 | |
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| 20. Round | 05/03/2022 | Lyon-La Duchère | - | FC Martigues | 2:2 | |
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| 21. Round | 12/03/2022 | GFA Rumilly Vallières | - | Lyon-La Duchère | 1:0 |  |
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| 22. Round | 19/03/2022 | Lyon-La Duchère | - | AS Saint-Priest | 2:3 | |
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| 23. Round | 26/03/2022 | Étoile FC | - | Lyon-La Duchère | 3:1 | |
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| 24. Round | 09/04/2022 | Lyon-La Duchère | - | GOAL FC | 1:0 | |
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| 25. Round | 16/04/2022 | Aubagne FC | - | Lyon-La Duchère | 1:1 | |
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| 26. Round | 23/04/2022 | Lyon-La Duchère | - | Jura Sud | 1:4 | |
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| 27. Round | 30/04/2022 | Olympique Marseille B | - | Lyon-La Duchère | 2:1 | ||||
| 28. Round | 14/05/2022 | Lyon-La Duchère | - | Marignane Gignac FC | 3:1 | |
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| 29. Round | 21/05/2022 | Olympique Lyonnais B | - | Lyon-La Duchère | 0:4 | |
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| 30. Round | 28/05/2022 | Lyon-La Duchère | - | RC Grasse | 0:3 |
Algeria