| 6. Round | 17/09/2005 | Sint-Truidense VV | - | Sporting Lokeren | 1:2 | ||||
| 7. Round | 21/09/2005 | Sporting Lokeren | - | KSK Beveren | 1:2 | ||||
| 8. Round | 24/09/2005 | Club Brugge KV | - | Sporting Lokeren | 0:1 | ||||
| 9. Round | 01/10/2005 | Standard Liège | - | Sporting Lokeren | 2:1 |  |
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| 10. Round | 15/10/2005 | Sporting Lokeren | - | Sporting Charleroi | 4:2 | ||||
| 11. Round | 22/10/2005 | KVC Westerlo | - | Sporting Lokeren | 1:1 | ||||
| 12. Round | 28/10/2005 | Sporting Lokeren | - | RSC Anderlecht | 2:2 | |
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| 13. Round | 04/11/2005 | KAA Gent | - | Sporting Lokeren | 1:2 | |
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| 14. Round | 19/11/2005 | Sporting Lokeren | - | SV Zulte Waregem | 2:3 | ||||
| 17. Round | 09/12/2005 | Germinal Beerschot | - | Sporting Lokeren | 2:1 | ||||
| 15. Round | 14/12/2005 | RAA La Louviére | - | Sporting Lokeren | 1:1 | ||||
| 18. Round | 17/12/2005 | KRC Genk | - | Sporting Lokeren | 2:2 | |
Togo