| 8. Round | 14/11/2020 | Alacranes de Durango | - | Leones Negros II | 4:2 | ||||
| 9. Round | 20/11/2020 | Leones Negros II | - | Cimarrones de Sonora II | 1:1 | ||||
| 10. Round | 05/12/2020 | Saltillo FC | - | Leones Negros II | 2:0 | ||||
| 11. Round | 12/12/2020 | Leones Negros II | - | Colima FC | 0:2 | ||||
| 12. Round | 16/01/2021 | Tecos Fútbol Club | - | Leones Negros II | 2:3 | ||||
| 14. Round | 29/01/2021 | Mazorqueros | - | Leones Negros II | 1:0 | ||||
| 16. Round | 12/02/2021 | Reboceros de La Piedad | - | Leones Negros II | 4:0 | ||||
| 17. Round | 22/02/2021 | Leones Negros II | - | Gavilanes de Matamoros | 0:1 | ||||
| 18. Round | 06/03/2021 | Tuzos de la UAZ | - | Leones Negros II | 1:0 | ||||
| 19. Round | 12/03/2021 | Leones Negros II | - | Alacranes de Durango | 1:4 | ||||
| 20. Round | 20/03/2021 | Cimarrones de Sonora II | - | Leones Negros II | 1:2 |  |
|||
| 21. Round | 03/04/2021 | Leones Negros II | - | Saltillo FC | 3:0 | ||||
| 22. Round | 12/04/2021 | Colima FC | - | Leones Negros II | 3:2 |
Mexico