| 1. Round | 19/09/2021 | Reboceros de La Piedad | - | Leviatán FC | 3:1 | ||||
| 2. Round | 25/09/2021 | Leviatán FC | - | Deportivo Dongu | 1:1 |  |
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| 3. Round | 02/10/2021 | Cañoneros FC | - | Leviatán FC | 4:0 |  |
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| 7. Round | 22/10/2021 | CD Zap | - | Leviatán FC | 3:0 | ||||
| 8. Round | 01/11/2021 | Leviatán FC | - | Inter de Querétaro | 0:3 | ||||
| 9. Round | 07/11/2021 | Montañeses FC | - | Leviatán FC | 0:1 | ||||
| 10. Round | 10/11/2021 | Leviatán FC | - | Inter Playa | 0:5 | |
Mexico