| 2. Round | 15/04/2018 | Seattle Sounders 2 | - | Rio Grande Valley FC | 3:2 | ||||
| 2. Round | 19/04/2018 | Portland Timbers 2 | - | Rio Grande Valley FC | 3:2 |  |
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| 3. Round | 02/05/2018 | Rio Grande Valley FC | - | Reno 1868 FC | 0:0 | ||||
| 3. Round | 10/05/2018 | Fresno FC | - | Rio Grande Valley FC | 2:2 | ||||
| 4. Round | 05/06/2018 | Real Monarchs SLC | - | Rio Grande Valley FC | 2:0 | ||||
| 4. Round | 17/06/2018 | OKC Energy FC | - | Rio Grande Valley FC | 3:1 | ||||
| 6. Round | 12/08/2018 | Sacramento Republic | - | Rio Grande Valley FC | 2:1 | ||||
| 6. Round | 19/08/2018 | Rio Grande Valley FC | - | OKC Energy FC | 2:4 | ||||
| 6. Round | 23/08/2018 | Los Angeles Galaxy II | - | Rio Grande Valley FC | 1:1 | ||||
| 7. Round | 06/09/2018 | Phoenix Rising | - | Rio Grande Valley FC | 1:0 | ||||
| 7. Round | 27/09/2018 | Reno 1868 FC | - | Rio Grande Valley FC | 4:0 |
Nigeria