| 1. Round | 11/07/2022 | CF Pachuca [Women] | - | Puebla FC [Women] | 3:0 |  |
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| 3. Round | 26/07/2022 | Santos Laguna [Women] | - | CF Pachuca [Women] | 3:2 | |
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| 4. Round | 28/07/2022 | CF Pachuca [Women] | - | Club León [Women] | 3:0 | ||||
| 5. Round | 01/08/2022 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 6. Round | 09/08/2022 | Club Tijuana [Women] | - | CF Pachuca [Women] | 3:3 | ||||
| 7. Round | 16/08/2022 | CF Pachuca [Women] | - | Gallos Blancos [Women] | 4:1 | ||||
| 8. Round | 20/08/2022 | UANL Tigres [Women] | - | CF Pachuca [Women] | 3:1 |  |
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| 11. Round | 12/09/2022 | Club Necaxa [Women] | - | CF Pachuca [Women] | 0:1 | |
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| 12. Round | 19/09/2022 | CF Pachuca [Women] | - | Pumas UNAM [Women] | 3:0 | ||||
| 13. Round | 23/09/2022 | CF Pachuca [Women] | - | Atlas Guadalajara [Women] | 4:0 | ||||
| 14. Round | 27/09/2022 | CF América [Women] | - | CF Pachuca [Women] | 2:1 | ||||
| 15. Round | 02/10/2022 | CF Pachuca [Women] | - | FC Juárez [Women] | 3:2 | ||||
| 17. Round | 25/10/2022 | Mazatlán FC [Women] | - | CF Pachuca [Women] | 3:1 |
USA
Mexico