| 1. Round | 17/03/2018 | Charlotte Independence | - | Ottawa Fury | 4:1 | ||||
| 1. Round | 24/03/2018 | Charlotte Independence | - | Toronto FC 2 | 2:0 | ||||
| 1. Round | 01/04/2018 | Charlotte Independence | - | Atlanta United II | 2:2 | ||||
| 3. Round | 20/05/2018 | Charlotte Independence | - | Toronto FC 2 | 2:1 | ||||
| 4. Round | 10/06/2018 | New York RB II | - | Charlotte Independence | 4:2 | ||||
| 4. Round | 17/06/2018 | Charlotte Independence | - | Charleston Battery | 1:1 |  |
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| 4. Round | 30/06/2018 | Bethlehem Steel FC | - | Charlotte Independence | 4:1 | ||||
| 5. Round | 08/07/2018 | Indy Eleven | - | Charlotte Independence | 2:1 | ||||
| 5. Round | 19/07/2018 | FC Cincinnati | - | Charlotte Independence | 2:0 | ||||
| 5. Round | 22/07/2018 | Louisville City FC | - | Charlotte Independence | 4:1 | ||||
| 5. Round | 29/07/2018 | Charlotte Independence | - | Penn FC | 1:1 | ||||
| 6. Round | 09/08/2018 | Charlotte Independence | - | Bethlehem Steel FC | 0:3 | ||||
| 6. Round | 23/08/2018 | Charlotte Independence | - | Louisville City FC | 0:3 |  |
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| 6. Round | 26/08/2018 | North Carolina FC | - | Charlotte Independence | 6:2 |
Zambia