| 2. Round | 31/07/2021 | FC Mynai | - | FK Oleksandriya | 1:0 | ||||
| 4. Round | 14/08/2021 | Zorya Lugansk | - | FC Mynai | 1:1 |  |
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| 6. Round | 29/08/2021 | FC Mynai | - | Shakhtar Donetsk | 1:1 | ||||
| 7. Round | 12/09/2021 | FC Mynai | - | Chernomorets Odessa | 2:2 | ||||
| 10. Round | 03/10/2021 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 | ||||
| 11. Round | 17/10/2021 | FC Mynai | - | Desna Chernigov | 0:0 | ||||
| 12. Round | 24/10/2021 | Rukh Lviv | - | FC Mynai | 2:2 | ||||
| 13. Round | 01/11/2021 | SK Dnipro-1 | - | FC Mynai | 4:0 | ||||
| 14. Round | 06/11/2021 | FC Mynai | - | FK Mariupol | 0:2 | |
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| 15. Round | 21/11/2021 | FC Mynai | - | Inhulets Petrove | 2:2 |  |
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| 16. Round | 27/11/2021 | FC Mynai | - | Dinamo Kiev | 0:2 | ||||
| 17. Round | 05/12/2021 | FK Oleksandriya | - | FC Mynai | 3:0 | ||||
| 18. Round | 12/12/2021 | Kolos Kovalivka | - | FC Mynai | 2:1 | |
Ukraine