| 1. Round | 12/03/2022 | Twente/Heracles [U21] | - | SBV Excelsior [U21] | 2:1 |  |
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| 2. Round | 19/03/2022 | FC Den Bosch [U21] | - | Twente/Heracles [U21] | 3:2 | ||||
| 4. Round | 09/04/2022 | Twente/Heracles [U21] | - | Go Ahead Eagles [U21] | 1:3 | |
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| 5. Round | 23/04/2022 | De Graafschap [U21] | - | Twente/Heracles [U21] | 1:1 | |
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| 6. Round | 07/05/2022 | Twente/Heracles [U21] | - | FC Emmen [U21] | 1:2 | |
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| 7. Round | 13/05/2022 | sc Heerenveen [U21] | - | Twente/Heracles [U21] | 1:4 |
Netherlands