18. Round | 12/09/2021 | Real Potosí | - | Real Tomayapo | 1:0 | ||||
19. Round | 17/09/2021 | San José | - | Real Potosí | 0:0 | ||||
20. Round | 22/09/2021 | Real Potosí | - | Real Santa Cruz | 3:0 | ||||
21. Round | 26/09/2021 | Nacional Potosí | - | Real Potosí | 4:2 | ||||
22. Round | 19/10/2021 | Real Potosí | - | Oriente Petrolero | 2:1 | ||||
23. Round | 23/10/2021 | The Strongest | - | Real Potosí | 1:0 | ||||
24. Round | 26/10/2021 | Real Potosí | - | Jorge Wilstermann | 2:2 | ||||
25. Round | 02/11/2021 | Atlético Palmaflor | - | Real Potosí | 0:1 | ||||
26. Round | 21/11/2021 | Real Potosí | - | Always Ready | 3:2 | ||||
27. Round | 28/11/2021 | Royal Pari | - | Real Potosí | 5:0 | ||||
29. Round | 05/12/2021 | Real Potosí | - | CD Guabirá | 1:3 | ||||
30. Round | 11/12/2021 | Blooming | - | Real Potosí | 1:0 |