| 2. Round | 15/01/2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 3. Round | 22/01/2022 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
| 4. Round | 29/01/2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
| 6. Round | 12/02/2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 |  |
|||
| 7. Round | 19/02/2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 | ||||
| 10. Round | 12/03/2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | ||||
| 11. Round | 19/03/2022 | CF Monterrey [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 15. Round | 16/04/2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 | ||||
| 16. Round | 23/04/2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 |
Mexico