| 1. Round | 12/01/2025 | Pumas UNAM | - | Club Necaxa | 2:1 | ||||
| 2. Round | 19/01/2025 | Gallos Blancos | - | Pumas UNAM | 3:2 |  |
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| 3. Round | 26/01/2025 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 4. Round | 30/01/2025 | Pumas UNAM | - | Deportivo Toluca | 1:1 | ||||
| 5. Round | 03/02/2025 | Atlético San Luis | - | Pumas UNAM | 2:3 |  |
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| 6. Round | 10/02/2025 | Pumas UNAM | - | Mazatlán FC | 1:0 | ||||
| 12. Round | 17/03/2025 | Pumas UNAM | - | CF Monterrey | 1:3 | ||||
| 13. Round | 31/03/2025 | Club León | - | Pumas UNAM | 1:2 | ||||
| 14. Round | 06/04/2025 | Cruz Azul | - | Pumas UNAM | 3:2 | ||||
| 15. Round | 13/04/2025 | Pumas UNAM | - | FC Juárez | 0:0 | ||||
| 16. Round | 17/04/2025 | Pumas UNAM | - | Santos Laguna | 2:0 | |
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| 17. Round | 20/04/2025 | UANL Tigres | - | Pumas UNAM | 2:1 |
Brazil