| 2. Round | 26/09/2021 | Yalmakan FC | - | Lobos ULMX | 1:0 | ||||
| 7. Round | 23/10/2021 | Escorpiones | - | Yalmakan FC | 0:1 | ||||
| 8. Round | 31/10/2021 | Yalmakan FC | - | Cafetaleros de Chiapas | 0:3 | ||||
| 12. Round | 21/11/2021 | Yalmakan FC | - | Leviatán FC | 10:0 | ||||
| 13. Round | 27/11/2021 | Sporting Canamy | - | Yalmakan FC | 0:3 |
Mexico