| 2. Round | 14/07/2022 | Atlético Junior | - | Atlético Nacional | 3:1 | ||||
| 3. Round | 17/07/2022 | La Equidad | - | Atlético Junior | 0:0 | ||||
| 4. Round | 24/07/2022 | Atlético Junior | - | Santa Fe | 2:0 |  |
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| 5. Round | 31/07/2022 | Águilas Doradas | - | Atlético Junior | 1:1 | ||||
| 6. Round | 08/08/2022 | Atlético Junior | - | Once Caldas | 1:2 | ||||
| 7. Round | 14/08/2022 | Atlético Junior | - | Independiente Medellín | 4:2 | ||||
| 8. Round | 21/08/2022 | América de Cali | - | Atlético Junior | 2:1 | ||||
| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 11. Round | 10/09/2022 | Atlético Junior | - | Deportivo Pereira | 0:0 | ||||
| 14. Round | 26/09/2022 | Alianza Petrolera | - | Atlético Junior | 0:1 | ||||
| 19. Round | 24/10/2022 | Atlético Junior | - | Cortuluá | 2:1 | ||||
| 20. Round | 30/10/2022 | Jaguares de Córdoba | - | Atlético Junior | 0:2 | |
Colombia