| 2. Round | 25/07/2021 | NK Maribor | - | NK Domžale | 3:1 | ||||
| 3. Round | 01/08/2021 | NK Domžale | - | NK Tabor Sežana | 1:1 | ||||
| 5. Round | 14/08/2021 | NK Domžale | - | NK Bravo | 0:2 | ||||
| 7. Round | 29/08/2021 | NK Domžale | - | NŠ Mura | 4:1 | ||||
| 8. Round | 11/09/2021 | NK Celje | - | NK Domžale | 3:1 | ||||
| 15. Round | 31/10/2021 | NK Domžale | - | NK Aluminij | 1:1 |  |
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| 16. Round | 07/11/2021 | NŠ Mura | - | NK Domžale | 1:1 | ||||
| 20. Round | 11/12/2021 | NK Maribor | - | NK Domžale | 1:0 |
Germany