| 1. Round | 17/07/2010 | Tacuary | - | Club Rubio Ñu | 0:0 |  |
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| 3. Round | 31/07/2010 | Tacuary | - | 3 de Febrero | 2:0 | ||||
| 4. Round | 07/08/2010 | Guaraní | - | Tacuary | 1:0 | ||||
| 5. Round | 15/08/2010 | Tacuary | - | Cerro Porteño | 0:1 | |
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| 6. Round | 21/08/2010 | Sport Colombia | - | Tacuary | 1:3 | ||||
| 7. Round | 28/08/2010 | Tacuary | - | Sol de América | 1:1 | ||||
| 8. Round | 05/09/2010 | Sportivo Trinidense | - | Tacuary | 1:1 | ||||
| 9. Round | 11/09/2010 | Tacuary | - | Sportivo Luqueño | 0:3 | ||||
| 10. Round | 19/09/2010 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 12. Round | 02/10/2010 | Club Rubio Ñu | - | Tacuary | 1:2 |  |
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| 14. Round | 16/10/2010 | 3 de Febrero | - | Tacuary | 0:0 | ||||
| 15. Round | 20/10/2010 | Tacuary | - | Guaraní | 1:1 | ||||
| 16. Round | 24/10/2010 | Cerro Porteño | - | Tacuary | 1:3 | ||||
| 17. Round | 30/10/2010 | Tacuary | - | Sport Colombia | 2:1 | |
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| 18. Round | 06/11/2010 | Sol de América | - | Tacuary | 0:1 | |
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| 19. Round | 13/11/2010 | Tacuary | - | Sportivo Trinidense | 0:1 | ||||
| 20. Round | 21/11/2010 | Sportivo Luqueño | - | Tacuary | 3:1 | ||||
| 21. Round | 27/11/2010 | Club Olimpia | - | Tacuary | 2:1 | |
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| 22. Round | 03/12/2010 | Tacuary | - | Club Nacional | 1:2 |
Paraguay