| 4. Round | 20/02/2021 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 6. Round | 06/03/2021 | Sol de América | - | Club Olimpia | 0:2 | ||||
| 7. Round | 10/03/2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
| 8. Round | 14/03/2021 | Sportivo Luqueño | - | Club Olimpia | 4:2 | ||||
| 9. Round | 21/03/2021 | Club Olimpia | - | River Plate | 5:1 | ||||
| 10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 11. Round | 11/04/2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 14. Round | 02/05/2021 | Cerro Porteño | - | Club Olimpia | 2:0 | ||||
| 15. Round | 09/05/2021 | Club Olimpia | - | Sol de América | 3:3 |  |
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| 16. Round | 17/05/2021 | Club Nacional | - | Club Olimpia | 2:1 |  |
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| 17. Round | 23/05/2021 | Club Olimpia | - | Sportivo Luqueño | 4:1 | |
Paraguay