| 1. Round | 07/03/2010 | Club San José | - | CD Guabirá | 3:0 |  |
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| 2. Round | 14/03/2010 | Club San José | - | The Strongest | 2:2 | ||||
| 3. Round | 19/03/2010 | Blooming | - | Club San José | 1:3 | |
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| 4. Round | 21/03/2010 | Club San José | - | Club Aurora | 0:1 | ||||
| 5. Round | 27/03/2010 | La Paz FC | - | Club San José | 4:2 | |
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| 6. Round | 01/04/2010 | Universitario de Sucre | - | Club San José | 2:3 | ||||
| 7. Round | 11/04/2010 | CD Guabirá | - | Club San José | 1:1 | ||||
| 9. Round | 24/04/2010 | Club San José | - | La Paz FC | 4:2 | ||||
| 10. Round | 29/04/2010 | Club San José | - | Blooming | 3:1 | ||||
| 11. Round | 02/05/2010 | Club Aurora | - | Club San José | 2:1 | |
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| 12. Round | 07/05/2010 | Club San José | - | Universitario de Sucre | 0:0 |
Paraguay