| 2. Round | 16/01/2022 | CF Pachuca [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 0:0 |  |
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| 5. Round | 12/02/2022 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 0:1 | ||||
| 6. Round | 19/02/2022 | Club León [U20] | - | Deportivo Guadalajara [U20] | 3:0 | ||||
| 7. Round | 26/02/2022 | Deportivo Guadalajara [U20] | - | Puebla FC [U20] | 2:0 | ||||
| 11. Round | 20/03/2022 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 4. Round | 29/03/2022 | FC Juárez [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 12. Round | 02/04/2022 | Deportivo Guadalajara [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 13. Round | 09/04/2022 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 14. Round | 16/04/2022 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 15. Round | 19/04/2022 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | |
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| 16. Round | 23/04/2022 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 3:1 | |
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| 17. Round | 29/04/2022 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 0:3 |
Mexico