| 1. Round | 19/02/2012 | Rampla Juniors | - | Defensor Sporting | 0:2 | ||||
| 2. Round | 26/02/2012 | Defensor Sporting | - | Nacional | 2:2 | ||||
| 3. Round | 04/03/2012 | Cerrito | - | Defensor Sporting | 0:2 |  |
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| 5. Round | 24/03/2012 | Fénix | - | Defensor Sporting | 0:1 | |
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| 6. Round | 01/04/2012 | Defensor Sporting | - | Liverpool | 4:2 | |
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| 4. Round | 05/04/2012 | Defensor Sporting | - | Peñarol | 0:0 | |
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| 8. Round | 14/04/2012 | Defensor Sporting | - | Racing | 5:1 | |
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| 9. Round | 22/04/2012 | CA Cerro | - | Defensor Sporting | 2:3 | |
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| 10. Round | 29/04/2012 | Defensor Sporting | - | Montevideo Wanderers | 2:1 | |
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| 12. Round | 13/05/2012 | Defensor Sporting | - | Cerro Largo | 2:1 | ||||
| 7. Round | 16/05/2012 | Rentistas | - | Defensor Sporting | 0:2 | ||||
| 13. Round | 20/05/2012 | Bella Vista | - | Defensor Sporting | 0:1 | |
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| 14. Round | 27/05/2012 | Defensor Sporting | - | El Tanque Sisley | 3:0 | |
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| 15. Round | 03/06/2012 | River Plate | - | Defensor Sporting | 2:1 | |
Uruguay