| 1. Round | 26/01/2025 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 2. Round | 30/01/2025 | Guaraní | - | General Caballero DJLM | 2:1 | ||||
| 3. Round | 03/02/2025 | 2 de Mayo | - | Guaraní | 0:2 | ||||
| 4. Round | 09/02/2025 | Guaraní | - | Libertad | 0:1 | ||||
| 5. Round | 15/02/2025 | Club Nacional | - | Guaraní | 1:2 | ||||
| 6. Round | 21/02/2025 | Guaraní | - | Deportivo Recoleta | 1:3 | ||||
| 7. Round | 02/03/2025 | Cerro Porteño | - | Guaraní | 0:1 | ||||
| 9. Round | 14/03/2025 | Guaraní | - | Atlético Tembetary | 0:0 | ||||
| 11. Round | 27/03/2025 | Guaraní | - | Sportivo Trinidense | 1:3 | ||||
| 12. Round | 06/04/2025 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 13. Round | 14/04/2025 | General Caballero DJLM | - | Guaraní | 0:0 | ||||
| 14. Round | 16/04/2025 | Guaraní | - | 2 de Mayo | 0:1 | ||||
| 19. Round | 18/05/2025 | Guaraní | - | Sportivo Ameliano | 1:3 | ||||
| 20. Round | 21/05/2025 | Atlético Tembetary | - | Guaraní | 1:2 |
Argentina