| 4. Round | 07/02/2022 | UANL Tigres | - | Mazatlán FC | 4:3 | ||||
| 5. Round | 12/02/2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 2. Round | 17/02/2022 | Mazatlán FC | - | CF América | 2:1 | ||||
| 6. Round | 19/02/2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 25/02/2022 | CF Pachuca | - | Mazatlán FC | 3:1 |  |
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| 8. Round | 02/03/2022 | Mazatlán FC | - | Club Necaxa | 0:0 | |
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| 10. Round | 12/03/2022 | CF Monterrey | - | Mazatlán FC | 2:1 |  |
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| 13. Round | 09/04/2022 | Mazatlán FC | - | Cruz Azul | 1:1 | ||||
| 14. Round | 15/04/2022 | Atlas Guadalajara | - | Mazatlán FC | 1:2 | ||||
| 15. Round | 20/04/2022 | Mazatlán FC | - | Santos Laguna | 1:0 | |
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| 16. Round | 23/04/2022 | FC Juárez | - | Mazatlán FC | 0:2 | ||||
| 17. Round | 30/04/2022 | Mazatlán FC | - | Puebla FC | 2:1 |
Chile