| 1. Round | 06/02/2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Round | 12/02/2022 | Plaza Colonia | - | River Plate | 0:1 |  |
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| 3. Round | 18/02/2022 | Cerro Largo | - | Plaza Colonia | 0:5 |  |
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| 5. Round | 12/03/2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Round | 19/03/2022 | Plaza Colonia | - | Albion | 1:1 | ||||
| 7. Round | 02/04/2022 | Nacional | - | Plaza Colonia | 1:0 | ||||
| 8. Round | 09/04/2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 9. Round | 17/04/2022 | Deportivo Maldonado | - | Plaza Colonia | 3:1 |  |
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| 11. Round | 07/05/2022 | Liverpool | - | Plaza Colonia | 1:0 | ||||
| 12. Round | 14/05/2022 | Plaza Colonia | - | Peñarol | 0:1 | ||||
| 13. Round | 23/05/2022 | Montevideo City Torque | - | Plaza Colonia | 1:1 | ||||
| 15. Round | 04/06/2022 | Cerrito | - | Plaza Colonia | 1:1 |
Uruguay