| 1. Round | 17/01/2021 | Fénix | - | River Plate | 0:3 dec. | ||||
| 2. Round | 20/01/2021 | River Plate | - | CA Cerro | 1:2 |  |
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| 4. Round | 04/02/2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Round | 08/02/2021 | Nacional | - | River Plate | 3:0 | ||||
| 8. Round | 17/02/2021 | River Plate | - | Rentistas | 1:1 | ||||
| 9. Round | 20/02/2021 | River Plate | - | Cerro Largo | 2:0 | ||||
| 10. Round | 27/02/2021 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 14. Round | 26/03/2021 | Plaza Colonia | - | River Plate | 1:0 | ||||
| 15. Round | 29/03/2021 | River Plate | - | Progreso | 3:2 | |
Uruguay