| 6. Round | 19/06/2021 | Sud América | - | River Plate | 1:2 | ||||
| 7. Round | 22/06/2021 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 8. Round | 26/06/2021 | Fénix | - | River Plate | 3:4 | ||||
| 9. Round | 03/07/2021 | River Plate | - | Boston River | 1:1 | ||||
| 11. Round | 17/07/2021 | River Plate | - | Rentistas | 0:0 | ||||
| 12. Round | 01/08/2021 | Peñarol | - | River Plate | 2:0 | ||||
| 14. Round | 15/08/2021 | Villa Española | - | River Plate | 1:1 |
Uruguay