| 6. Round | 16/10/2021 | Liverpool | - | Plaza Colonia | 0:1 | ||||
| 7. Round | 20/10/2021 | Plaza Colonia | - | River Plate | 0:0 | ||||
| 8. Round | 25/10/2021 | Cerro Largo | - | Plaza Colonia | 1:0 | ||||
| 9. Round | 30/10/2021 | Plaza Colonia | - | Progreso | 2:1 | ||||
| 10. Round | 04/11/2021 | Sud América | - | Plaza Colonia | 1:1 | ||||
| 11. Round | 09/11/2021 | Plaza Colonia | - | Deportivo Maldonado | 1:0 |  |
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| 12. Round | 14/11/2021 | Plaza Colonia | - | Fénix | 1:1 | ||||
| 13. Round | 22/11/2021 | Boston River | - | Plaza Colonia | 2:0 | ||||
| 14. Round | 26/11/2021 | Plaza Colonia | - | Montevideo Wanderers | 0:1 | ||||
| 15. Round | 04/12/2021 | Rentistas | - | Plaza Colonia | 2:3 |
Uruguay
Italy