| 1. Round | 21/07/2018 | Atlético San Luis | - | Mineros de Zacatecas | 0:0 | ||||
| 2. Round | 28/07/2018 | TM Fútbol Club | - | Atlético San Luis | 1:2 |  |
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| 3. Round | 04/08/2018 | Atlético San Luis | - | Venados FC | 1:0 | |
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| 4. Round | 11/08/2018 | Atlético San Luis | - | Atlético Zacatepec | 0:0 | |
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| 5. Round | 19/08/2018 | Club Celaya | - | Atlético San Luis | 0:4 | |
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| 7. Round | 02/09/2018 | FC Juárez | - | Atlético San Luis | 1:0 | ||||
| 8. Round | 15/09/2018 | Atlético San Luis | - | Potros UAEM | 1:2 | |
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| 9. Round | 22/09/2018 | Cimarrones de Sonora | - | Atlético San Luis | 1:1 | |
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| 10. Round | 29/09/2018 | Atlético San Luis | - | Correcaminos UAT | 1:0 | |
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| 11. Round | 06/10/2018 | Atlante | - | Atlético San Luis | 2:3 | |
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| 12. Round | 20/10/2018 | Atlético San Luis | - | Cafetaleros de Tapachula | 3:1 | |
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| 13. Round | 27/10/2018 | Alebrijes de Oaxaca | - | Atlético San Luis | 1:0 | ||||
| 14. Round | 03/11/2018 | Atlético San Luis | - | Leones Negros | 0:0 | |
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| 15. Round | 11/11/2018 | Dorados de Sinaloa | - | Atlético San Luis | 1:1 | |
Argentina
Mexico