| 1. Round | 13/02/2023 | Santiago Wanderers | - | Santa Cruz | 0:0 | ||||
| 2. Round | 20/02/2023 | Santa Cruz | - | Rangers | 2:2 |  |
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| 4. Round | 05/03/2023 | Universidad de Concepción | - | Santa Cruz | 0:1 | ||||
| 5. Round | 14/03/2023 | Santa Cruz | - | Barnechea | 1:0 |  |
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| 6. Round | 20/03/2023 | Puerto Montt | - | Santa Cruz | 1:2 | ||||
| 7. Round | 27/03/2023 | Santa Cruz | - | Santiago Morning | 1:1 | ||||
| 9. Round | 23/04/2023 | Santa Cruz | - | Cobreloa | 1:1 | ||||
| 10. Round | 28/04/2023 | Recoleta | - | Santa Cruz | 2:1 | ||||
| 12. Round | 16/05/2023 | San Luis | - | Santa Cruz | 4:1 | ||||
| 13. Round | 23/05/2023 | Santa Cruz | - | San Marcos | 1:0 | |
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| 14. Round | 28/05/2023 | Deportes Iquique | - | Santa Cruz | 1:0 | |
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| 15. Round | 05/06/2023 | Santa Cruz | - | Deportes Temuco | 1:1 |  |
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| 17. Round | 09/07/2023 | Rangers | - | Santa Cruz | 2:1 | ||||
| 18. Round | 18/07/2023 | La Serena | - | Santa Cruz | 0:3 | ||||
| 20. Round | 30/07/2023 | Barnechea | - | Santa Cruz | 1:0 | ||||
| 24. Round | 21/09/2023 | Cobreloa | - | Santa Cruz | 2:0 | |
Chile