| 4. Round | 04/02/2021 | Plaza Colonia | - | CA Cerro | 2:1 | ||||
| 5. Round | 07/02/2021 | CA Cerro | - | Progreso | 2:0 | ||||
| 6. Round | 11/02/2021 | Fénix | - | CA Cerro | 3:3 | ||||
| 7. Round | 14/02/2021 | CA Cerro | - | Liverpool | 1:1 | ||||
| 8. Round | 18/02/2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 9. Round | 22/02/2021 | Danubio | - | CA Cerro | 2:1 | ||||
| 10. Round | 27/02/2021 | CA Cerro | - | Nacional | 0:1 | ||||
| 11. Round | 06/03/2021 | Boston River | - | CA Cerro | 2:0 |  |
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| 12. Round | 13/03/2021 | CA Cerro | - | Deportivo Maldonado | 2:3 | ||||
| 13. Round | 19/03/2021 | Rentistas | - | CA Cerro | 0:1 | ||||
| 15. Round | 29/03/2021 | Montevideo Wanderers | - | CA Cerro | 1:1 | |
Uruguay