| 1. Round | 03/02/2025 | CA Cerro | - | River Plate | 1:1 |  |
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| 2. Round | 08/02/2025 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 3. Round | 17/02/2025 | Montevideo City Torque | - | River Plate | 2:1 | ||||
| 4. Round | 24/02/2025 | River Plate | - | Peñarol | 1:1 | ||||
| 5. Round | 08/03/2025 | Nacional | - | River Plate | 3:3 | ||||
| 6. Round | 18/03/2025 | River Plate | - | Boston River | 0:2 |  |
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| 8. Round | 26/03/2025 | Racing | - | River Plate | 1:0 | ||||
| 9. Round | 29/03/2025 | River Plate | - | Plaza Colonia | 1:2 | ||||
| 10. Round | 06/04/2025 | Liverpool | - | River Plate | 0:0 | ||||
| 11. Round | 14/04/2025 | River Plate | - | Juventud de Las Piedras | 1:0 | |
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| 14. Round | 05/05/2025 | Miramar Misiones | - | River Plate | 3:0 | |
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| 15. Round | 17/05/2025 | River Plate | - | Montevideo Wanderers | 0:1 |
Uruguay